There is no standard dosing that fits everyone.
Much comes into play when you’re looking at the right amount of cannabinoids for an individual — personal metabolism, genetics, hormone levels, how much you’ve eaten, and how you feel that day in general.
THC in lower doses soothes both anxiety and depression.
Some patients get nervous about trying THC, but starting with a small amount and working up to the desired goal can be a way to avoid unwanted effects. A small puff of sativa lifts a mood and motivates without causing anxiety and a very low-dose Sativa edible or sublingual preparation can create the same effect.
CBD is an excellent solution for treating depression and anxiety.
High-CBD flowers, edibles and sublinguals are available in many different ratios. I explain to patients that cannabidiol is about homeostasis rather than euphoria. CBD generally takes people to a base level where they can be functional and calm without the grogginess of benzodiazepines. Experimentation with various ratios is essential, as we all metabolize cannabinoids differently. More balanced ratios (1:1-1:4) often are helpful for depression while larger ratios (18:1 and higher) are exceptionally useful for anxiety and anxiety-causing disorders such as OCD. As with THC, microdosing is key — the goal is to find the optimal amount for balance and relief in the body. It’s important to note that large amounts of high-ratio CBD can act as a depressant.
Strain selection is important for appropriate therapy.
Different strains contain specific terpene profiles that influence effects. Sativas are uplifting and for overcoming a depressive episode. Some strains can exacerbate anxiety — another reason microdosing is the best approach to successful medicating. Hybrids are effective for both depression and anxiety. They can range from calming and functional to uplifting and creative. Be aware of strains that cause negative effects for you personally and look out for those genetics in new strains you try. Indicas can be helpful for anxiety, but be careful when you’re dealing with depression as they can exacerbate mood, making it harder to get out of bed or leave the house if there is too much sedation.
All plants, including cannabis, have naturally-occurring terpene molecules, which create the unique scents of strains and display specific effects in the body.
Terpenes that alleviate depression are beta caryophyllene (β-caryophyllene) and limonene. Beta caryophyllene, one of the more common terpenes found in cannabis, can be found in hops and black pepper and is known to have more stimulating effects. Limonene, more often found in sativa-dominant strains, is also found in citrus and has uplifting antidepressant properties. Terpenes that help anxiety are linalool and myrcene (β-myrcene). Linalool, primarily in indica-dominant strains, has anti-anxiety properties and is found in lavender. Myrcene, another common terpene found in cannabis that is also in mangoes. Note that both terpenes have sedating properties not ideal for treating depression.
Mode of medication is important.
Smoking/vaporizing cannabis metabolizes differently in the body than consuming edibles. When smoking or vaporizing dried flowers the effects are felt almost immediately, including the therapeutic effects of the flower’s terpenes. Edibles are great for microdosing and have a longer therapeutic effect. Higher dosages of edibles can be problematic — the way we metabolize them produces a drowsier feeling towards the end of the experience whether they be sativa or indica which is undesirable in cases of depression. They can also create a next-day “stoned-over” effect, which can make motivation difficult.
It’s amazing to have patients come in to say they’ve been able to stop taking Xanax, Ativan, etc. These drugs are debilitating, addictive and make it hard to have a functional and productive lifestyle. As cannabis use evolves and becomes normalized, people are discovering they can take control of their depression and anxiety on their own terms using natural medicine that lacks the side effects of pharmaceuticals.
TELL US, have you used cannabis to treat your depression or anxiety? What were the results?